"HbA1c is predictive of pregnancy outcomes in women with known diabetes, so we weren't that surprised," Dr. This is lower than the currently recommended 6.5% threshold, they note in Diabetes Care, online September 4. NEW YORK A1c level of 5.9% or higher is optimal for detecting diabetes and for identifying women at increased risk of adverse pregnancy outcomes, according to researchers from New Zealand. Hba1c Cutoff Of 5.9% Best For Detecting Diabetes In Pregnancy From each patient 5 c.c blood was taken & HbA1C level was measured with the help of enzymatic method. Estimation of serum HbA1C level was done in all patient in each trimester. During this study period, 100 pregnant patient with diabetes who attended or admitted at BIRDEM Hospital were studied. The study was carried out in the department of Obstetrics and Gynaecology in BIRDEM Hospital during the period of September 2006 to August 2007. Materials and Methods: It was prospective observational study. HbA1C Level in 2nd and 3rd Trimester with Pregnancy Outcome in Diabetic Patients Ruma Sengupta, Soha Jesmen, laila Arjuman Banu, Samir Humyra Habib Objective: The present study was undertaken to determine the association of maternal serum HbA1C level with maternal and fetal outcome. Hba1c Level In 2nd And 3rd Trimester With Pregnancy Outcome In Diabetic Patients Br J Obstet Gynaecol 86:210213, Glycaemic control is associated with pre- te Worth R, Potter JM, Drury J, Fraser RB, globins. American Diabetes Association: Precon- 10. Marshall SM, Barth JH: Standardization of 9. Kilpatrick ES: Glycated haemoglobin in 8. Hartland AJ, Smith JM, Clark PMS, Web- trol and complications trial-aligned HbA1c 7. Diabeto- type 1 diabetes mellitus: a major potential factor underlying macrosomia (Editorial). Diabetolo- pre-eclampsia in type I diabetes. This might explain why we 10, and is sustained during the remaining level was not measured in this study, and the third trimester of pregnancy, indicat- wide study in the Netherlands. (5), who investigated 267 in these two studies. (6), who studied 493 healthy Hartland et al. 1200 DIABETES CARE, VOLUME 27, NUMBER 5, MAY 2004 OKane et al. 2004 by the American Diabetes Association. Abbreviations: DCCT, Diabetes Control and Complications Trial OGTT, oral glucose tolerance test. holds stocks in and receives grant support from Novo Nordisk. E- Received for publication 19 January 2004 and accepted in revised form 20 January 2004. Address correspondence and reprint requests to Elisabeth Mathiesen, Department of Endocrinology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Sparsely investigated with different meth- (5,6,11,12), and reference ranges are gen- All subjects had a random capillary blood based on risk factors for gestational dia- Department of Endocrinology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Department of Obstetrics, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Steno Diabetes Center, Copenhagen, Denmark and the Odense University Hospital, Odense, Denmark. Hba1c Levels Are Significantly Lower In Early And Late Pregnancy Detecting women who are diabetic even before conception is ve This clearly showed that they (33 women) did not develop diabetes during pregnancy but were already diabetic (even before conception). Balaji and others found that 33 of the 507 women tested had HBA1C above 6. The paper published in the Diabetes Care journal last year by Dr. So the HBA1C test when done at the time of first visit, especially when the OGTT value is abnormal, can help in distinguishing the true GDM cases from the other. This is because HBA1C provides the average concentration of blood glucose during the weeks previous to testing. Unlike the OGTT, the HBA1C test is equipped to tell if a woman has been a diabetic even before conception. But such testing has a limitation it cannot tell if the woman is truly a GDM case or a diabetic even prior to conception. The conventional way to detect GDM is through oral glucose tolerance tests (OGTT). Women who are already diabetic but become aware of their disease at the time of pregnancy cannot be classified as having gestational diabetes. But, the way pregnant women are tested for GDM makes it difficult to say with surety that the disease has indeed been developed only during pregnancy. HBA1C test should be done at first visit especially when GTT tests abnormal Women who develop diabetes during pregnancy are said to have gestational diabetes (GDM). HBA1C test can tell if a woman has been a diabetic even before conception. They also found that, a HBA1C level at the first visit of less than 5.3 would not develop gestational diabetes during the entire course of pregnancy. The study showed that 7% of women diagnosed with gestational diabetes were already diabetic at the time of first visit and were misdiagnosed with gestational diabetes, when they had diabetes.
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